Hepatocellular carcinoma: H-Prune gene regulatory networks

H∞ Sampled-Data Controller Design for Stochastic Genetic Regulatory Networks

Artificially regulating gene expression is an important step in developing new treatment for system-level disease such as cancer. In this paper, we propose a method to regulate gene expression based on sampled-data measurements of gene products concentrations. Inherent noisy behaviour of Gene regulatory networks are modeled with stochastic nonlinear differential equation. To synthesize feed...

Hepatocellular Carcinoma in Sheep

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...

Gene Regulatory Networks

Tryptophan is one of the 20 amino acids that link together to form proteins. For humans it is an essential amino acid, we must get it from our diet since we cannot synthesize it. E. coli bacterial cells, however, can synthesize the amino acid tryptophan when it is not provided from the environment (e.g. the gut where it lives). It would be wasteful to synthesize tryptophan when it is readily av...

Gene-centered regulatory networks.

Differential gene expression plays a critical role in the development and physiology of multicellular organisms. At a 'systems level' (e.g. at the level of a tissue, organ or whole organism), this process can be studied using gene regulatory network (GRN) models that capture physical and regulatory interactions between genes and their regulators. In the past years, significant progress has been...